Crystallization (Comment) | Organism |
---|---|
docking studies of inhibitors (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid, and 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid | low micromolar inhibition of both isochorismate lyase and anthranilate synthase | Mycobacterium tuberculosis | |
3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid | low micromolar inhibition of both isochorismate lyase and anthranilate synthase | Mycobacterium tuberculosis | |
3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid | low micromolar inhibition of both isochorismate lyase and anthranilate synthase | Mycobacterium tuberculosis | |
3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid | low micromolar inhibition of both isochorismate lyase and anthranilate synthase | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
isochorismate | pH 8.0, 25°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isochorismate | - |
Mycobacterium tuberculosis | salicylate + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
salicylate synthase | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.8 | - |
isochorismate | pH 8.0, 25°C | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid | pH 8.0, 25°C | Mycobacterium tuberculosis | |
0.013 | - |
(E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid | pH 8.0, 25°C | Mycobacterium tuberculosis | |
0.014 | - |
3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid | pH 8.0, 25°C | Mycobacterium tuberculosis | |
0.021 | - |
3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid | pH 8.0, 25°C | Mycobacterium tuberculosis |