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Literature summary for 4.2.99.18 extracted from

  • Sepulveda, S.; Valenzuela, L.; Ponce, I.; Sierra, S.; Bahamondes, P.; Ramirez, S.; Rojas, V.; Kemmerling, U.; Galanti, N.; Cabrera, G.
    Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi (2014), J. Cell. Biochem., 115, 397-409.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
methoxamine
-
Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus of epimastigote, constitutively expressed Trypanosoma cruzi 5634
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi T1SGV2
-
-
Trypanosoma cruzi T1SHD4
-
-
Trypanosoma cruzi Dm28c T1SGV2
-
-
Trypanosoma cruzi Dm28c T1SHD4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote enzyme is present and active in the two replicative parasite forms, epimastigotes and amastigotes, as well as in the nonreplicative, infective trypomastigotes Trypanosoma cruzi
-
epimastigote enzyme is present and active in the two replicative parasite forms, epimastigotes and amastigotes, as well as in the nonreplicative, infective trypomastigotes Trypanosoma cruzi
-
trypomastigote enzyme is present and active in the two replicative parasite forms, epimastigotes and amastigotes, as well as in the nonreplicative, infective trypomastigotes Trypanosoma cruzi
-

Synonyms

Synonyms Comment Organism
AP-endonuclease 1
-
Trypanosoma cruzi
AP-endonuclease 2
-
Trypanosoma cruzi
Ap1
-
Trypanosoma cruzi
Ap2
-
Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function overexpression of isoform AP1 increases epimastigotes viability when they are exposed to acute ROS/RNS attack. This protective effect is more evident when parasites are submitted to persistent reactive oxygen species/reactive nitrogen species exposition Trypanosoma cruzi