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Literature summary for 4.2.99.18 extracted from

  • Park, W.S.; Ko, E.A.; Jung, I.D.; Son, Y.K.; Kim, H.K.; Kim, N.; Park, S.Y.; Hong, K.W.; Park, Y.M.; Choi, T.H.; Han, J.
    APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+ channel in human endothelial cells via suppression of NADPH oxidase (2008), Arch. Pharm. Res., 31, 1291-1301.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information expression of AdAPE1/Ref-1 is significantly higher in cells transfected with AdAPE1/Ref-1 than in the control cells (5.3-fold) demonstrating that infection with AdAPE1/Ref-1 can significantly increase the amount of cytoplasmic APE1/Ref-1 in human umbilical vein endothelial cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
adenoviruses full-length APE1/Ref-1 (AdAPE1/Ref-1) is generated by homologous recombination in human embryonic kidney 293 cells. Human umbilical vein endothelial cells are infected with 200 multiplicity of infection Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+-channel in human endothelial cells via suppression of NADPH oxidase ?
-
?
additional information Homo sapiens APE1/Ref-1 reduces oxidative stress by regulating the level of reactive oxygen species in the cytoplasm ?
-
?
additional information Homo sapiens overexpression of APE1/Ref-1 suppressed angiotensin II induced production of superoxide and hydrogen peroxide ?
-
?
additional information Homo sapiens The BK-Ca current in APE1/Ref-1-overexpressing human umbilical vein endothelial cells is similarly inhibited by angiotensin II, except that inhibition of 43.06% is achieved using only 10 nM angiotensin II ?
-
?
additional information Homo sapiens ubiquitously expressed protein that functions as both an endonuclease in the repair of oxidatively damaged DNA and an aid in the binding of redox-sensitive transcription factors ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell line human umbilical vein endothelial cells are infected with adenovirus encoding APE/Ref-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+-channel in human endothelial cells via suppression of NADPH oxidase Homo sapiens ?
-
?
additional information APE1/Ref-1 reduces oxidative stress by regulating the level of reactive oxygen species in the cytoplasm Homo sapiens ?
-
?
additional information overexpression of APE1/Ref-1 suppressed angiotensin II induced production of superoxide and hydrogen peroxide Homo sapiens ?
-
?
additional information The BK-Ca current in APE1/Ref-1-overexpressing human umbilical vein endothelial cells is similarly inhibited by angiotensin II, except that inhibition of 43.06% is achieved using only 10 nM angiotensin II Homo sapiens ?
-
?
additional information ubiquitously expressed protein that functions as both an endonuclease in the repair of oxidatively damaged DNA and an aid in the binding of redox-sensitive transcription factors Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AdAPE1/Ref-1
-
Homo sapiens
APE1/Ref-1
-
Homo sapiens
Apurinic/apyrimidinic endonuclease1/redox factor 1
-
Homo sapiens