Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of AdAPE1/Ref-1 is significantly higher in cells transfected with AdAPE1/Ref-1 than in the control cells (5.3-fold) demonstrating that infection with AdAPE1/Ref-1 can significantly increase the amount of cytoplasmic APE1/Ref-1 in human umbilical vein endothelial cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
adenoviruses full-length APE1/Ref-1 (AdAPE1/Ref-1) is generated by homologous recombination in human embryonic kidney 293 cells. Human umbilical vein endothelial cells are infected with 200 multiplicity of infection | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+-channel in human endothelial cells via suppression of NADPH oxidase | ? | - |
? | |
additional information | Homo sapiens | APE1/Ref-1 reduces oxidative stress by regulating the level of reactive oxygen species in the cytoplasm | ? | - |
? | |
additional information | Homo sapiens | overexpression of APE1/Ref-1 suppressed angiotensin II induced production of superoxide and hydrogen peroxide | ? | - |
? | |
additional information | Homo sapiens | The BK-Ca current in APE1/Ref-1-overexpressing human umbilical vein endothelial cells is similarly inhibited by angiotensin II, except that inhibition of 43.06% is achieved using only 10 nM angiotensin II | ? | - |
? | |
additional information | Homo sapiens | ubiquitously expressed protein that functions as both an endonuclease in the repair of oxidatively damaged DNA and an aid in the binding of redox-sensitive transcription factors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell line | human umbilical vein endothelial cells are infected with adenovirus encoding APE/Ref-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+-channel in human endothelial cells via suppression of NADPH oxidase | Homo sapiens | ? | - |
? | |
additional information | APE1/Ref-1 reduces oxidative stress by regulating the level of reactive oxygen species in the cytoplasm | Homo sapiens | ? | - |
? | |
additional information | overexpression of APE1/Ref-1 suppressed angiotensin II induced production of superoxide and hydrogen peroxide | Homo sapiens | ? | - |
? | |
additional information | The BK-Ca current in APE1/Ref-1-overexpressing human umbilical vein endothelial cells is similarly inhibited by angiotensin II, except that inhibition of 43.06% is achieved using only 10 nM angiotensin II | Homo sapiens | ? | - |
? | |
additional information | ubiquitously expressed protein that functions as both an endonuclease in the repair of oxidatively damaged DNA and an aid in the binding of redox-sensitive transcription factors | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AdAPE1/Ref-1 | - |
Homo sapiens |
APE1/Ref-1 | - |
Homo sapiens |
Apurinic/apyrimidinic endonuclease1/redox factor 1 | - |
Homo sapiens |