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Literature summary for 4.2.99.18 extracted from

  • Chang, I.Y.; Kim, S.H.; Cho, H.J.; Lee do, Y.; Kim, M.H.; Chung, M.H.; You, H.J.
    Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability (2005), Nucleic Acids Res., 33, 5073-5081.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the APE-mediated decrease in expression of MSH6 protein results in a reduced cellular mismatch repair capacity as well as the increased generation of microsatellite instability. The potential role of APE to generate microsatellite instability may have clinically important implications for cancer susceptibility and carcinogenesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the function of APE is considered as the rate-limiting step in DNA base excision repair. AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast GM00637 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the function of APE is considered as the rate-limiting step in DNA base excision repair. AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AP endonuclease
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Homo sapiens
Ape
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Homo sapiens