Application | Comment | Organism |
---|---|---|
medicine | the APE-mediated decrease in expression of MSH6 protein results in a reduced cellular mismatch repair capacity as well as the increased generation of microsatellite instability. The potential role of APE to generate microsatellite instability may have clinically important implications for cancer susceptibility and carcinogenesis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the function of APE is considered as the rate-limiting step in DNA base excision repair. AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | GM00637 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the function of APE is considered as the rate-limiting step in DNA base excision repair. AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP endonuclease | - |
Homo sapiens |
Ape | - |
Homo sapiens |