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Literature summary for 4.2.99.18 extracted from

  • Marenstein, D.R.; Chan, M.K.; Altamirano, A.; Basu, A.K.; Boorstein, R.J.; Cunningham, R.P.; Teebor, G.W.
    Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity (2003), J. Biol. Chem., 278, 9005-9012.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
APE1 APE1, a human homolog of Escherichia coli exonuclease III Xth stimulates under conditions of Vmax Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme is inhibited by the product of its DNA N-glycosylase activity directed against Tg:G, the AP:G site, but not inhibited by the AP:A site arising from release of Tg from Tg:A Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Homo sapiens
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?
DNA rate of AP lyase-mediated strand cleavage is much slower than the rate of DNA N-glycoxsylase-mediated base release Homo sapiens fragments of DNA
-
?