Literature summary for 4.2.3.9 extracted from

Shishova, E.Y.; Di Costanzo, L.; Cane, D.E.; Christianson, D.W.
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate (2007), Biochemistry, 46, 1941-1951.

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Cloned(Commentary)

Cloned (Comment)	Organism
into the pET11 vector for expression in Escherichia coli BL21DE3pLysS cells	Aspergillus terreus

Crystallization (Commentary)

Crystallization (Comment)	Organism
the structure of recombinant aristolochene synthase at a resolution of 2.2 A and its complex with diphosphate and three Mg2+ ions at 2.15 A is reported	Aspergillus terreus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Aspergillus terreus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
70000	-	dimer, native gel analysis	Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	Aspergillus terreus	-	aristolochene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus terreus	Q9UR08	-	-

Purification (Commentary)

Purification (Comment)	Organism
using DE52 anion exchange resin, a methyl HIC, a Sephadex G-25, and a High Q column	Aspergillus terreus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	-	Aspergillus terreus	aristolochene + diphosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Aspergillus terreus

Synonyms

Synonyms	Comment	Organism
aristolochene synthase	-	Aspergillus terreus

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Release 2023.1 (January 2023)