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Literature summary for 4.2.3.74 extracted from

  • Wang, C.; Hopson, R.; Lin, X.; Cane, D.
    Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol (2009), J. Am. Chem. Soc., 131, 8360-8361.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.3.74

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Botrytis cinerea

Organism

Organism UniProt Comment Textmining
Botrytis cinerea
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O
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 Botrytis cinerea presilphiperfolan-8beta-ol + diphosphate
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 ?
additional information the conversion of (2E,6E)-farnesyl diphosphate to presilphiperfolan-8beta-ol involves initial formation of the humulyl cation which then cyclizes to the 2-epicaryophyllenyl ion. Following ring expansion and further cyclization, the resultant tricyclic cation undergoes a 1,3-hydride shift to generate the presilphiperfolan-8-yl cation which is then quenched by capture of water to give presilphiperfolan-8beta-ol Botrytis cinerea ?
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 ?

Synonyms

Synonyms Comment Organism
BOT2
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 Botrytis cinerea
PSPS
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 Botrytis cinerea

General Information

General Information Comment Organism
malfunction inactivation of the BOT2 gene results in strain-dependent loss of virulence Botrytis cinerea
metabolism the BOT2 gene encodes the sesquiterpene synthase that is responsible for the committed step in the biosynthesis of botrydial Botrytis cinerea