BRENDA - Enzyme Database
show all sequences of 4.2.3.7

Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate. Anti stereochemistry in a biological SE reaction

Cane, D.E.; Abell, C.; Lattman, R.; Kane, C.T.; Hubbard, B.R.; Harrison, P.H.M.; J. Am. Chem. Soc. 110, 4081-4082 (1988)
No PubMed abstract available

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
farnesyl diphosphate
Streptomyces sp.
-
pentalenene + diphosphate
-
Streptomyces sp.
?
farnesyl diphosphate
Streptomyces sp. UC5319
-
pentalenene + diphosphate
-
Streptomyces sp. UC5319
?
Organism
Organism
UniProt
Commentary
Textmining
Streptomyces sp.
-
UC5319
-
Streptomyces sp. UC5319
-
UC5319
-
Reaction
Reaction
Commentary
Organism
Reaction ID
(2E,6E)-farnesyl diphosphate = pentalenene + diphosphate
mechanism
Streptomyces sp.
(2E,6E)-farnesyl diphosphate = pentalenene + diphosphate
stereochemistry
Streptomyces sp.
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
farnesyl diphosphate
-
648599
Streptomyces sp.
pentalenene + diphosphate
-
648599
Streptomyces sp.
?
farnesyl diphosphate
trans,trans
648599
Streptomyces sp.
pentalenene + diphosphate
-
648599
Streptomyces sp.
?
farnesyl diphosphate
-
648599
Streptomyces sp. UC5319
pentalenene + diphosphate
-
648599
Streptomyces sp. UC5319
?
farnesyl diphosphate
trans,trans
648599
Streptomyces sp. UC5319
pentalenene + diphosphate
-
648599
Streptomyces sp. UC5319
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
farnesyl diphosphate
Streptomyces sp.
-
pentalenene + diphosphate
-
Streptomyces sp.
?
farnesyl diphosphate
Streptomyces sp. UC5319
-
pentalenene + diphosphate
-
Streptomyces sp. UC5319
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
farnesyl diphosphate
-
648599
Streptomyces sp.
pentalenene + diphosphate
-
648599
Streptomyces sp.
?
farnesyl diphosphate
trans,trans
648599
Streptomyces sp.
pentalenene + diphosphate
-
648599
Streptomyces sp.
?
farnesyl diphosphate
-
648599
Streptomyces sp. UC5319
pentalenene + diphosphate
-
648599
Streptomyces sp. UC5319
?
farnesyl diphosphate
trans,trans
648599
Streptomyces sp. UC5319
pentalenene + diphosphate
-
648599
Streptomyces sp. UC5319
?
Other publictions for EC 4.2.3.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748049
Pemberton
General base-general acid cat ...
Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
J. Antibiot.
69
486-493
2016
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2
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7
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748539
Rosso
-
GRID/BIOCUBE4mf to rank the i ...
Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
Med. Chem. Res.
24
2612-2620
2015
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-
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-
11
-
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10
-
1
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2
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4
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1
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11
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10
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2
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729884
Zu
Effect of isotopically sensiti ...
Streptomyces exfoliatus
J. Am. Chem. Soc.
134
11369-11371
2012
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1
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1
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730085
Melillo
Heterologous expression of pen ...
Streptomyces exfoliatus
J. Biotechnol.
161
302-307
2012
-
1
1
-
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10
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1
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1
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-
-
-
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-
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1
1
-
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-
680353
Gutta
Theoretical studies on farnesy ...
Streptomyces exfoliatus
J. Am. Chem. Soc.
128
6172-6179
2006
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-
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1
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1
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1
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1
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1
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648604
Seemann
Pentalenene synthase. Analysis ...
Streptomyces exfoliatus
J. Am. Chem. Soc.
124
7681-7689
2002
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7
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3
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7
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-
648603
Seemann
-
Pentalenene synthase. Histidin ...
Streptomyces exfoliatus
J. Am. Chem. Soc.
121
591-592
1999
-
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-
4
-
-
1
-
-
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1
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1
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4
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1
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1
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648602
Lesburg
Crystal structure of pentalene ...
Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
Science
277
1820-1824
1997
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1
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4
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1
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721000
Lesburg
Crystallization and preliminar ...
Streptomyces exfoliatus
Protein Sci.
4
2436-2438
1995
-
-
1
1
-
-
-
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1
1
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5
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1
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1
1
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1
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1
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1
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1
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1
1
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648600
Cane
Pentalenene synthase. Purifica ...
Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
Biochemistry
33
5846-5857
1994
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1
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1
1
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1
1
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13
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1
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2
1
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1
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1
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1
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1
1
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1
1
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1
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2
1
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1
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648601
Cane
-
Cyclization of farnesyl diphos ...
Streptomyces sp., Streptomyces sp. UC5319
Can. J. Chem.
72
118-127
1994
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6
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1
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648598
Cane
-
The biosynthesis of pentalenen ...
Streptomyces sp., Streptomyces sp. UC5319
J. Am. Chem. Soc.
112
4513-4524
1990
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2
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6
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1
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4
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4
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648599
Cane
-
Pentalenene biosynthesis and t ...
Streptomyces sp., Streptomyces sp. UC5319
J. Am. Chem. Soc.
110
4081-4082
1988
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-
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2
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6
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4
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648597
Cane
Partial purification and chara ...
Streptomyces sp., Streptomyces sp. UC5319
Arch. Biochem. Biophys.
254
421-429
1987
-
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3
1
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2
1
2
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8
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1
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1
1
6
-
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1
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1
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3
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1
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1
2
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1
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1
1
6
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1
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1
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648596
Cane
Cell-free studies of monoterpe ...
Streptomyces sp., Streptomyces sp. UC5319
Biochem. Soc. Trans.
11
510-515
1983
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2
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6
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