Literature summary for 4.2.3.6 extracted from

Cane, D.E.; Pawlak, J.L.; Horak, R.M.
Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate (1990), Biochemistry, 29, 5476-5490.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(7R)-(E)-6,7-dihydrofarnesyl diphosphate	-	Fusarium sporotrichioides
(7S)-(E)-6,7-dihydrofarnesyl diphosphate	modestly competitive	Fusarium sporotrichioides

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(E,E)-farnesyl diphosphate	Fusarium sporotrichioides	-	trichodiene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Fusarium sporotrichioides	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate	mechanism	Fusarium sporotrichioides	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7S)-6,7-dihydrofarnesyl diphosphate	-	Fusarium sporotrichioides	dihydrofarnesene isomers + (E)-6,7-dihydrofarnesol + (3S,7S)-6,7-dihydronerolidol	-	?
(E,E)-farnesyl diphosphate	-	Fusarium sporotrichioides	trichodiene + diphosphate	-	?
(E,E)-farnesyl diphosphate	formation of trichodiene involves initial generation of (3R)-nerolidyl diphosphate	Fusarium sporotrichioides	trichodiene + diphosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00022	-	(7R)-(E)-6,7-dihydrofarnesyl diphosphate	-	Fusarium sporotrichioides
0.000395	-	(7S)-(E)-6,7-dihydrofarnesyl diphosphate	-	Fusarium sporotrichioides

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Release 2023.1 (January 2023)