Literature summary for 4.2.3.56 extracted from

  • Steele, C.L.; Crock, J.; Bohlmann, J.; Croteau, R.
    Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase (1998), J. Biol. Chem., 273, 2078-2089.
    View publication on PubMed

Metals/Ions

Metals/Ions Commentary Organism Structure
additional information does not utilize K+ in the cyclization reaction Abies grandis
Mg2+ gamma-humulene synthase can utilize Mg2+ or Mn2+ with comparable velocities in the cyclization reaction Abies grandis
Mn2+ gamma-humulene synthase can utilize Mg2+ or Mn2+ with comparable velocities in the cyclization reaction Abies grandis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Commentary Organism
67940
-
calculated from amino acid sequence Abies grandis

Organism

Organism UniProt Commentary Textmining
Abies grandis O64405 grand fir
-

Source Tissue

Source Tissue Commentary Organism Textmining
seed
-
Abies grandis
-

Substrates and Products (Substrate)

Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility Substrate Product ID
(2E,6E)-farnesyl diphosphate
-
715436 Abies grandis gamma-humulene + diphosphate main product with 28.6% yield
-
-
?
additional information gamma-humulene synthase produces mainly gamma-humulene (28.6% yield) from (2E,6E)-farnesyl diphosphate, further products are sibirene (15.1% yield), longifolene (11.8% yield), beta-himachalene (7.2% yield), alpha-himachalene (4.8% yield), beta-bisabolene (3.9% yield), alpha-longipinene (3.4% yield), sativene (3.1% yield), alpha-ylangene (2.7% yield), beta-gurjunene (2.0% yield), gamma-bisabolene (1.9% yield), beta-longipinene (1.5% yield), (E)-beta-farnesene (1.3% yield), (E)-alpha-bisabolene (0.9% yield), delta-amorphene and alpha-amorphene (0.5% yield each), beta-ylangene (0.3% yield), 1,5,9-trimethylcyclododeca-1,5,9-triene and longicyclene (0.2% yield each), as well as beta-cubebene, alpha-copaene, alpha-cubebene, (Z,E)-germacrene B, and cyclosativene (0.1% yield each), along with 26 unknown sesquiterpene olefins (4.1% total yield) 715436 Abies grandis ?
-
-
-
?

Synonyms

Synonyms Commentary Organism
gamma-humulene synthase
-
Abies grandis

Metals/Ions (protein specific)

Metals/Ions Commentary Organism Structure
additional information does not utilize K+ in the cyclization reaction Abies grandis
Mg2+ gamma-humulene synthase can utilize Mg2+ or Mn2+ with comparable velocities in the cyclization reaction Abies grandis
Mn2+ gamma-humulene synthase can utilize Mg2+ or Mn2+ with comparable velocities in the cyclization reaction Abies grandis

Molecular Weight [Da] (protein specific)

Molecular Weight [Da] Molecular Weight Maximum [Da] Commentary Organism
67940
-
calculated from amino acid sequence Abies grandis

Source Tissue (protein specific)

Source Tissue Commentary Organism Textmining
seed
-
Abies grandis
-

Substrates and Products (Substrate) (protein specific)

Substrates Commentary Substrates Literature (Substrates) Organism Products Commentary (Products) Literature (Products) Organism (Products) Reversibility ID
(2E,6E)-farnesyl diphosphate
-
715436 Abies grandis gamma-humulene + diphosphate main product with 28.6% yield
-
-
?
additional information gamma-humulene synthase produces mainly gamma-humulene (28.6% yield) from (2E,6E)-farnesyl diphosphate, further products are sibirene (15.1% yield), longifolene (11.8% yield), beta-himachalene (7.2% yield), alpha-himachalene (4.8% yield), beta-bisabolene (3.9% yield), alpha-longipinene (3.4% yield), sativene (3.1% yield), alpha-ylangene (2.7% yield), beta-gurjunene (2.0% yield), gamma-bisabolene (1.9% yield), beta-longipinene (1.5% yield), (E)-beta-farnesene (1.3% yield), (E)-alpha-bisabolene (0.9% yield), delta-amorphene and alpha-amorphene (0.5% yield each), beta-ylangene (0.3% yield), 1,5,9-trimethylcyclododeca-1,5,9-triene and longicyclene (0.2% yield each), as well as beta-cubebene, alpha-copaene, alpha-cubebene, (Z,E)-germacrene B, and cyclosativene (0.1% yield each), along with 26 unknown sesquiterpene olefins (4.1% total yield) 715436 Abies grandis ?
-
-
-
?