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Literature summary for 4.2.3.4 extracted from

  • Negron, L.; Parker, E.
    Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase (2011), Org. Biomol. Chem., 9, 2861-2867.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
-
Pyrococcus furiosus
-
Actinidia chinensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
0.002
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
0.0032
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
0.0037
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
0.0057
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
0.0087
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
0.021
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
0.029
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
0.064
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37397
-
x * 37397, electrospray ionisation mass spectrometry Pyrococcus furiosus
38888
-
x * 38888, electrospray ionisation mass spectrometry Escherichia coli
45189
-
x * 45189, electrospray ionisation mass spectrometry, His-tagged protein Actinidia chinensis

Organism

Organism UniProt Comment Textmining
Actinidia chinensis
-
-
-
Escherichia coli
-
-
-
Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Escherichia coli (6R)-6-fluoro-dehydroquinate
-
?
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Pyrococcus furiosus (6R)-6-fluoro-dehydroquinate
-
?
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Actinidia chinensis (6R)-6-fluoro-dehydroquinate
-
?
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Escherichia coli (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Pyrococcus furiosus (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Actinidia chinensis (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Escherichia coli 3-dehydroquinate + phosphate
-
?
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Pyrococcus furiosus 3-dehydroquinate + phosphate
-
?
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Actinidia chinensis 3-dehydroquinate + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 37397, electrospray ionisation mass spectrometry Pyrococcus furiosus
? x * 38888, electrospray ionisation mass spectrometry Escherichia coli
? x * 45189, electrospray ionisation mass spectrometry, His-tagged protein Actinidia chinensis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
0.3
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
0.5
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
0.9
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
1.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
2.5
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
3
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
3.3
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
16
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
14
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
14.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
34.5
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
44.8
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
156
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
811
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
1562
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
1650
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
2807
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli