Literature summary for 4.2.3.39 extracted from

Jackson, B.E.; Hart-Wells, E.A.; Matsuda, S.P.
Metabolic engineering to produce sesquiterpenes in yeast (2003), Org. Lett., 5, 1629-1632.

Cloned(Commentary)

Cloned (Comment)	Organism
functional expression in Saccharomyces cerevisiae, native mating type alpha yeast strain JBY574 and constructed strain EHY42, leading to production of sesquiterpenes in yeast. Expressing epi-cedrol synthase in the upc2-1 mutant CJ-2A actually decreases foreign sesquiterpene yields relative to wild-type strain. FPP is apparently less accessible to the epi-cedrol synthase in the upc2-1 mutant, overview. Mating type influences foreign sesquiterpene production, overview	Artemisia annua

Cloned (Comment)

Organism

functional expression in Saccharomyces cerevisiae, native mating type alpha yeast strain JBY574 and constructed strain EHY42, leading to production of sesquiterpenes in yeast. Expressing epi-cedrol synthase in the upc2-1 mutant CJ-2A actually decreases foreign sesquiterpene yields relative to wild-type strain. FPP is apparently less accessible to the epi-cedrol synthase in the upc2-1 mutant, overview. Mating type influences foreign sesquiterpene production, overview

Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + H2O	Artemisia annua	-	8-epi-cedrol + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + H2O	-	Artemisia annua	8-epi-cedrol + diphosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)