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Literature summary for 4.2.3.24 extracted from
- In vitro metabolic engineering of amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production (2017), ACS Synth. Biol., 6, 1691-1700 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | about 20% inhibition at 15 mM | Artemisia annua |  |
| ATP | more than 5fold reduction in enzyme activity at 15 mM ATP | Artemisia annua | |
| CTP | potent inhibitor, 75fold inhibition at 10 mM | Artemisia annua | |
| diphosphate | potent inhibitor | Artemisia annua | |
| additional information | not inhibited by phosphomevalonic acid | Artemisia annua |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Artemisia annua | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate | Artemisia annua | - |
amorpha-4,11-diene + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Artemisia annua | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate | - |
Artemisia annua | amorpha-4,11-diene + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADS | - |
Artemisia annua |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.33 | - |
at pH and °C | Artemisia annua | diphosphate | |
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Release 2023.1 (January 2023)
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