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Literature summary for 4.2.3.2 extracted from
- Kinetic characterization of the human O-phosphoethanolamine phospho-lyase reveals unconventional features of this specialized pyridoxal phosphate-dependent lyase (2015), FEBS J., 282, 183-199 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-Aminopropylphosphonate | - |
Homo sapiens |  |
| ethylsulfonate | - |
Homo sapiens | |
| methylsulfonate | - |
Homo sapiens | |
| phosphate | competitive inhibitor at pH values between 6.0 and 8.0 | Homo sapiens | |
| sulfate | competitive inhibitor at pH values between 6.0 and 8.0 | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
Ethanolamine phosphate | at pH 7.4 and 30°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethanolamine phosphate + H2O | Homo sapiens | - |
acetaldehyde + NH3 + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethanolamine phosphate + H2O | - |
Homo sapiens | acetaldehyde + NH3 + phosphate | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGXT2L1 | - |
Homo sapiens |
| ETNPPL | - |
Homo sapiens |
| O-phosphoethanolamine phospho-lyase | - |
Homo sapiens |
| PEA phospho-lyase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.9 | - |
Ethanolamine phosphate | at pH 6.0 and 30°C | Homo sapiens | |
| 1.2 | - |
Ethanolamine phosphate | at pH 7.4 and 30°C | Homo sapiens | |
| 2.3 | - |
Ethanolamine phosphate | at pH 8.0 and 30°C | Homo sapiens | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.5 | - |
sulfate | at pH 6.0 and 30°C | Homo sapiens | |
| 1.5 | - |
phosphate | at pH 8.0 and 30°C | Homo sapiens | |
| 1.5 | - |
sulfate | at pH 8.0 and 30°C | Homo sapiens | |
| 8 | - |
phosphate | at pH 6.0 and 30°C | Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
Ethanolamine phosphate | at pH 7.4 and 30°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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