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Literature summary for 4.2.3.193 extracted from
- Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms (2016), J. Antibiot., 69, 515-523 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli and in an engineered Streptomyces host.Recombinant SCLAV_p0490 forms insoluble proteins | Streptomyces cyslabdanicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+)-copalyl diphosphate | Streptomyces cyslabdanicus | - |
labda-8(17),12,14-triene + diphosphate | - |
? |  |
| labda-7,13-dienyl diphosphate | Streptomyces cyslabdanicus | - |
labda-7,12,14-triene + diphosphate | - |
? | |
| additional information | Streptomyces cyslabdanicus | the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-12 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces cyslabdanicus | A0A0H5BN57 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+)-copalyl diphosphate | - |
Streptomyces cyslabdanicus | labda-8(17),12,14-triene + diphosphate | - |
? | |
| labda-7,13-dienyl diphosphate | - |
Streptomyces cyslabdanicus | labda-7,12,14-triene + diphosphate | - |
? | |
| additional information | the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-12 | Streptomyces cyslabdanicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CldD | - |
Streptomyces cyslabdanicus |
| labdatriene synthase | - |
Streptomyces cyslabdanicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB | Streptomyces cyslabdanicus |
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