Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and in an engineered Streptomyces host.Recombinant SCLAV_p0490 forms insoluble proteins | Streptomyces clavuligerus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-copalyl diphosphate | Streptomyces clavuligerus | - |
labda-8(17),13(16),14-triene + diphosphate | - |
? | |
(+)-copalyl diphosphate | Streptomyces clavuligerus DSM 738 | - |
labda-8(17),13(16),14-triene + diphosphate | - |
? | |
labda-7,13-dienyl diphosphate | Streptomyces clavuligerus | - |
labda-7,13(16),14-triene + diphosphate | - |
? | |
labda-7,13-dienyl diphosphate | Streptomyces clavuligerus DSM 738 | - |
labda-7,13(16),14-triene + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | B5GRC8 | - |
- |
Streptomyces clavuligerus DSM 738 | B5GRC8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-copalyl diphosphate | - |
Streptomyces clavuligerus | labda-8(17),13(16),14-triene + diphosphate | - |
? | |
(+)-copalyl diphosphate | - |
Streptomyces clavuligerus DSM 738 | labda-8(17),13(16),14-triene + diphosphate | - |
? | |
labda-7,13-dienyl diphosphate | - |
Streptomyces clavuligerus | labda-7,13(16),14-triene + diphosphate | - |
? | |
labda-7,13-dienyl diphosphate | - |
Streptomyces clavuligerus DSM 738 | labda-7,13(16),14-triene + diphosphate | - |
? | |
additional information | the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16 | Streptomyces clavuligerus | ? | - |
? | |
additional information | the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16 | Streptomyces clavuligerus DSM 738 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCLAV_p0491 | - |
Streptomyces clavuligerus |
General Information | Comment | Organism |
---|---|---|
physiological function | in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB | Streptomyces clavuligerus |