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Literature summary for 4.2.3.18 extracted from

  • Peters, R.J.; Ravn, M.M.; Coates, R.M.; Croteau, R.B.
    Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites (2001), J. Am. Chem. Soc., 123, 8974-8978.
    View publication on PubMed
Search for more literature for 4.2.3.18

Protein Variants

Protein Variants Comment Organism
D404A unreactive with geranylgeranyl diphosphate Abies grandis
D621A unreactive with (+)-copalyl diphosphate Abies grandis

Inhibitors

Inhibitors Comment Organism Structure
14,15-dihydro-15-azageranylgeranyl diphosphate
-
 Abies grandis
geranylgeranyl diphosphate substrate inhibition Abies grandis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00035
-
 copalyl diphosphate
-
 Abies grandis
0.0004
-
 copalyl diphosphate D404A Abies grandis
132
-
 copalyl diphosphate
-
 Abies grandis
138
-
 copalyl diphosphate mutant D404A Abies grandis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
 gel filtration Abies grandis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-copalyl-diphosphate Abies grandis
-
 (-)-abietadiene + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Abies grandis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-copalyl-diphosphate
-
 Abies grandis (-)-abietadiene + diphosphate
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Abies grandis