Literature summary for 4.2.3.16 extracted from

Croteau, R.; Alonso, W.R.; Koepp, A.E.; Shim, J.H.; Cane, D.E.
Irreversible inactivation of monoterpene cyclases by a mechanism-based inhibitor (1993), Arch. Biochem. Biophys., 307, 397-404.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate	Ki: 0.0003 mM, irreversible covalent modification	Mentha sp.
diethyl dicarbonate	-	Mentha sp.
p-hydroxymercuribenzoate	-	Mentha sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranyl diphosphate	Mentha sp.	-	(-)-(4S)-limonene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mentha sp.	-	M. spicata	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	glandular trichome secretory cells	Mentha sp.	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranyl diphosphate	-	Mentha sp.	(-)-(4S)-limonene + diphosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0003	-	6-cyclopropylidene-(3E)-methyl-hex-2-en-1-yl diphosphate	irreversible covalent modification	Mentha sp.

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Release 2023.1 (January 2023)