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Literature summary for 4.2.3.152 extracted from

  • Stratmann, A.; Mahmud, T.; Lee, S.; Distler, J.; Floss, H.G.; Piepersberg, W.
    The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose (1999), J. Biol. Chem., 274, 10889-10896.
    View publication on PubMed
Search for more literature for 4.2.3.152

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed heterologously in Streptomyces lividans 66 Actinoplanes sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ assay bufer contains Co2+ Actinoplanes sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-sedoheptulose 7-phosphate Actinoplanes sp. the cyclization product, 2-epi-5-epi-valiolone is a precursor of the valienamine moiety of acarbose 2-epi-5-epi-valiolone + phosphate
-
 ?
D-sedoheptulose 7-phosphate Actinoplanes sp. 50/110 the cyclization product, 2-epi-5-epi-valiolone is a precursor of the valienamine moiety of acarbose 2-epi-5-epi-valiolone + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Actinoplanes sp. Q9ZAE9
-
-
Actinoplanes sp. 50/110 Q9ZAE9
-
-

Storage Stability

Storage Stability Organism
-20°C, AcbC extract can be stored for 3 months without major loss of activity Actinoplanes sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-sedoheptulose 7-phosphate the cyclization product, 2-epi-5-epi-valiolone is a precursor of the valienamine moiety of acarbose Actinoplanes sp. 2-epi-5-epi-valiolone + phosphate
-
 ?
D-sedoheptulose 7-phosphate no activity with ido-heptulose 7-phosphate Actinoplanes sp. 2-epi-5-epi-valiolone + phosphate
-
 ?
D-sedoheptulose 7-phosphate the cyclization product, 2-epi-5-epi-valiolone is a precursor of the valienamine moiety of acarbose Actinoplanes sp. 50/110 2-epi-5-epi-valiolone + phosphate
-
 ?
D-sedoheptulose 7-phosphate no activity with ido-heptulose 7-phosphate Actinoplanes sp. 50/110 2-epi-5-epi-valiolone + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AbcC
-
 Actinoplanes sp.
C7-cyclitol synthase
-
 Actinoplanes sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Actinoplanes sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Actinoplanes sp.

Cofactor

Cofactor Comment Organism Structure
NAD+ assay buffer contains NAD+ Actinoplanes sp.