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Literature summary for 4.2.3.152 extracted from
- Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838 (2008), Appl. Microbiol. Biotechnol., 80, 637-645.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces albus |
| overexpressed in Escherichia coli | Streptomyces albus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50500 | - |
x * 50500, SDS-PAGE, His-tagged recombinant protein | Streptomyces albus |
| 50550 | - |
x * 50550, polyhistidine-tagged protein, SDS-PAGE | Streptomyces albus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-sedoheptulose 7-phosphate | Streptomyces albus | the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose | 2-epi-5-epi-valiolone + phosphate | - |
? |  |
| D-sedoheptulose 7-phosphate | Streptomyces albus ATCC 21838 | the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose | 2-epi-5-epi-valiolone + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces albus | A8D7K2 | - |
- |
| Streptomyces albus ATCC 21838 | A8D7K2 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces albus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-sedoheptulose 7-phosphate | the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose | Streptomyces albus | 2-epi-5-epi-valiolone + phosphate | - |
? | |
| D-sedoheptulose 7-phosphate | SalQ has high specificity for sedoheptulose 7-phosphate as substrate. No activity with D-glucose 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate and D-ribose 5-phosphate | Streptomyces albus | 2-epi-5-epi-valiolone + phosphate | - |
? | |
| D-sedoheptulose 7-phosphate | the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose | Streptomyces albus ATCC 21838 | 2-epi-5-epi-valiolone + phosphate | - |
? | |
| D-sedoheptulose 7-phosphate | SalQ has high specificity for sedoheptulose 7-phosphate as substrate. No activity with D-glucose 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate and D-ribose 5-phosphate | Streptomyces albus ATCC 21838 | 2-epi-5-epi-valiolone + phosphate | - |
? | |
| additional information | no substrates: amino 3-deoxy-D-arabino-heptulosonate 7-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate, glucose 6-phosphate, fructose 6-phosphate, mannose 6-phosphate, and ribose 5-phosphate | Streptomyces albus | ? | - |
? | |
| additional information | no substrates: amino 3-deoxy-D-arabino-heptulosonate 7-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate, glucose 6-phosphate, fructose 6-phosphate, mannose 6-phosphate, and ribose 5-phosphate | Streptomyces albus ATCC 21838 | ? | - |
? | |
| sedoheptulose 7-phosphate | - |
Streptomyces albus | 2-epi-5-epi-valiolone + phosphate | - |
? | |
| sedoheptulose 7-phosphate | - |
Streptomyces albus ATCC 21838 | 2-epi-5-epi-valiolone + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50550, polyhistidine-tagged protein, SDS-PAGE | Streptomyces albus |
| ? | x * 50500, SDS-PAGE, His-tagged recombinant protein | Streptomyces albus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SalQ | - |
Streptomyces albus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Streptomyces albus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Streptomyces albus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose | Streptomyces albus |
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