Literature summary for 4.2.3.13 extracted from

  • Alchanati, I.; Acreman Patel, J.A.; Liu, J.; Benedict, C.R.; Stipanovic, R.D.; Bell, A.A.; Cui, Y.; Magill, C.W.
    The enzymatic cyclization of nerolidyl diphosphate by delta-cadinene synthase from cotton stele tissue infected with Verticillium dahlia (1998), Phytochemistry, 47, 961-967.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-trans,6-trans-farnesyl diphosphate Gossypium barbadense the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether (+)-delta-cadinene + diphosphate
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?

Organism

Organism UniProt Comment Textmining
Gossypium barbadense
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cv. Seabrook 12B2
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Gossypium barbadense
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sea island cotton
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Source Tissue

Source Tissue Comment Organism Textmining
stele infected with Verticillium dahliae. Verticillium dahliae initiates a signal in the stele tissue that results in an increased steady-state level of delta-cadinene synthase mRNA and an increased activity of delta-cadinene synthase Gossypium barbadense
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans,6-trans-farnesyl diphosphate nerolidyl diphosphate is an intermediate Gossypium barbadense (+)-delta-cadinene + diphosphate
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?
2-trans,6-trans-farnesyl diphosphate the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether Gossypium barbadense (+)-delta-cadinene + diphosphate
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?
nerolidyl diphosphate
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Gossypium barbadense (+)-delta-cadinene + diphosphate
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?