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Literature summary for 4.2.3.121 extracted from

  • Croteau, R.; Satterwhite, D.M.
    Biosynthesis of monoterpenes: Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage (1989), J. Biol. Chem., 264, 15309-15315.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
geranyl diphosphate pH 6.5, 30°C Salvia officinalis
0.004
-
(3R)-linalyl diphosphate pH 6.5, 30°C Salvia officinalis
0.0049
-
(3S)-linalyl diphosphate pH 6.5, 30°C Salvia officinalis
0.006
-
neryl diphosphate pH 6.5, 30°C Salvia officinalis

Organism

Organism UniProt Comment Textmining
Salvia officinalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R)-linalyl diphosphate
-
Salvia officinalis (+)-alpha-pinene + diphosphate products are 62% (+)-alpha-pinene, 6% camphene, 11% limonene, 7% terpinolene, 10% myrcene, 1% cis-ocimene, 4% trans-ocimene ?
(3S)-linalyl diphosphate
-
Salvia officinalis (+)-alpha-pinene + diphosphate products are 9% (+)-alpha-pinene, 9% camphene, 34% limonene, 28%% terpinolene, 11% myrcene, 2% cis-ocimene, 6% trans-ocimene ?
geranyl diphosphate
-
Salvia officinalis (+)-alpha-pinene + diphosphate products are 49% (+)-alpha-pinene, 30% camphene, 10% limonene, 5% terpinolene, 6% myrcene ?
additional information reaction follows a cisoid,anti-endo-pattern. In the case of geranyl diphosphate, a preassociation mechanism is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step. The alternate substrates are ionized by the cyclases prior to their achieving the optimum orientation for bicyclization Salvia officinalis ?
-
?
neryl diphosphate
-
Salvia officinalis (+)-alpha-pinene + diphosphate products are 14% (+)-alpha-pinene, 9% camphene, 62% limonene, 8% terpinolene, 6% myrcene ?

Synonyms

Synonyms Comment Organism
(+)-pinene cyclase
-
Salvia officinalis