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Literature summary for 4.2.3.12 extracted from

  • Leitner, K.L.; Meyer, M.; Leimbacher, W.; Peterbauer, A.; Hofer, S.; Heufler, C.; Mueller, A.; Heller, R.; Werner, E.R.; Thoeny, B.; Werner-Felmayer, G.
    Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase (2003), Biochem. J., 373, 681-688.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin Homo sapiens 23 bp exon 3 skipping in transcription rather than post-transcriptional mechanisms is a major cause of the low PTPS protein expression in human macrophages and related cell types. The exon lacking leads to a premature stop codon encoding for a shorter protein instead of the full-length functional enzyme 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
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?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin Homo sapiens the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q03393
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-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
-
Homo sapiens 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin 23 bp exon 3 skipping in transcription rather than post-transcriptional mechanisms is a major cause of the low PTPS protein expression in human macrophages and related cell types. The exon lacking leads to a premature stop codon encoding for a shorter protein instead of the full-length functional enzyme Homo sapiens 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway Homo sapiens 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
?