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Literature summary for 4.2.3.108 extracted from
- Identification of the first bacterial monoterpene cyclase, a 1,8-cineole synthase, that catalyzes the direct conversion of geranyl diphosphate (2011), ChemBioChem, 12, 1988-1991.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces clavuligerus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00017 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, SDS-PAGE | Streptomyces clavuligerus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces clavuligerus | B5GMG2 | - |
- |
| Streptomyces clavuligerus DSM 738 | B5GMG2 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranyl diphosphate + H2O | - |
Streptomyces clavuligerus | 1,8-cineole + diphosphate | 1,8-cineole is the single major product | ? | |
| geranyl diphosphate + H2O | - |
Streptomyces clavuligerus DSM 738 | 1,8-cineole + diphosphate | 1,8-cineole is the single major product | ? | |
| additional information | no substrate: farnesyl diphosphate | Streptomyces clavuligerus | ? | - |
? | |
| additional information | no substrate: farnesyl diphosphate | Streptomyces clavuligerus DSM 738 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40000, SDS-PAGE | Streptomyces clavuligerus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCLAV_p0982 | - |
Streptomyces clavuligerus |
| SSCG_00536 | - |
Streptomyces clavuligerus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.079 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 460 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus | |
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