Literature summary for 4.2.3.104 extracted from

Sonntag, F.; Kroner, C.; Lubuta, P.; Peyraud, R.; Horst, A.; Buchhaupt, M.; Schrader, J.
Engineering Methylobacterium extorquens for de novo synthesis of the sesquiterpenoid alpha-humulene from methanol (2015), Metab. Eng., 32, 82-94 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene zssI, recombinant coexpression of alpha-humulene synthase of Zingiber zerumbet from codon-optimized gene zssI with farnesyl diphosphate (FPP) synthase from Saccharomyces cerevisiae leads to concentrations of up to 18 mg/l alpha-humulene in Methylobacterium extorquens strain AM1, cloning scheme comprising genes zssI and ERG20	Zingiber zerumbet

Protein Variants

Protein Variants	Comment	Organism
additional information	potential of Methylobacterium extorquens as a future platform host for the production of high-value terpenoids from the alternative carbon source methanol. Inducible recombinant coexpression of alpha-humulene synthasefrom Zingiber zerumbet with farnesyl diphosphate (FPP) synthase from Saccharomyces cerevisiae leads to concentrations of up to 18 mg/l alpha-humulene in Methylobacterium extorquens strain AM1. Extracellular alpha-humulene has no growth inhibiting effect on Methylobacterium extorquens strain AM1 up to concentrations of 1 g/l. Method evaluation, overview	Zingiber zerumbet

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate	Zingiber zerumbet	-	alpha-humulene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Zingiber zerumbet	B1B1U3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate	-	Zingiber zerumbet	alpha-humulene + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
zssI	-	Zingiber zerumbet

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Release 2023.1 (January 2023)