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Literature summary for 4.2.3.1 extracted from

  • Lee, M.; Martin, M.N.; Hudson, A.O.; Lee, J.; Muhitch, M.J.; Leustek, T.
    Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana (2005), Plant J., 41, 685-696.
    View publication on PubMed
Search for more literature for 4.2.3.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in transgenic Arabidopsis Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-phospho-L-homoserine + H2O Escherichia coli threonine synthesis in eukaryotes L-threonine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
O-phospho-L-homoserine + H2O = L-threonine + phosphate reaction proceeds via phosphate removal and isomerization from primary to secondary alcohol Escherichia coli
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 homozygous line from plant 829-2 exhibits 10.1fold and 2.1fold higher activity without and with 0.2 mmol/l S-adenosyl methionine compared to wild type. Homozygous line from plant 829-9 exhibits 25.2fold and 3.8fold higher activity without and with 0.2 mmol/l S-adenosyl methionine compared to wild type. Homozygous line from plant 829-14 exhibits 6.5fold and 1.5fold higher activity without and with 0.2 mmol/l S-adenosyl methionine compared to wild type Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-homoserine + H2O threonine synthesis in eukaryotes Escherichia coli L-threonine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
threonine synthase
-
 Escherichia coli