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Literature summary for 4.2.3.1 extracted from

  • Laber, B.; Gerbling, K.P.; Harde, C.; Neff, K.H.; Nordhoff, E.; Pohlenz, H.D.
    Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors (1994), Biochemistry, 33, 3413-3423.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
DL-2-amino-3[(phosphonomethyl)thio]propionic acid Ki: 0.057 mM, kinact: 1.44 min-1 Escherichia coli
DL-E-2-amino-5-phosphono-4-pentenoic acid Ki: 0.54 mM Escherichia coli
L-2,3-methanohomoserine phosphate Ki: 0.01 mM Escherichia coli
L-2-amino-3[(phosphonomethyl)thio]propionic acid Ki: 0.011 mM Escherichia coli
L-3-hydroxyhomoserine Ki: 0.05 mM Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
O-phosphohomoserine
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
O-phospho-L-homoserine + H2O = L-threonine + phosphate mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-3-chloroalanine beta-elimination Escherichia coli pyruvate + NH3 + HCl
-
ir
DL-vinylglycine + H2O
-
Escherichia coli L-threonine
-
ir
L-allo-threonine + H2O beta-elimination Escherichia coli 2-oxobutyrate + NH3
-
ir
L-serine beta-elimination Escherichia coli pyruvate + NH3
-
ir
additional information half-transamination reactions Escherichia coli ?
-
?
threonine beta-elimination Escherichia coli 2-oxobutyrate + NH3
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7.33
-
O-phosphohomoserine
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
L-2,3-methanohomoserine phosphate
-
Escherichia coli
0.011
-
L-2-amino-3[(phosphonomethyl)thio]propionic acid
-
Escherichia coli
0.05
-
L-3-hydroxyhomoserine
-
Escherichia coli
0.057
-
DL-2-amino-3[(phosphonomethyl)thio]propionic acid kinact: 1.44 min-1 Escherichia coli
0.54
-
DL-E-2-amino-5-phosphono-4-pentenoic acid
-
Escherichia coli