Literature summary for 4.2.2.7 extracted from

Yu, G.; LeBrun, L.; Gunay, N.S.; Hoppensteadt, D.; Walenga, J.M.; Fareed, J.; Linhardt, R.J.
Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site (2000), Thromb. Res., 100, 549-556.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.018	-	heparin pentasaccharide	cleavage of a synthetic pentasaccharide containing an antithrombin III binding site into a trisaccharide and a disaccharide, pH 7.0, 30ºC	Pedobacter heparinus

Organism

Organism	UniProt	Comment	Textmining
Pedobacter heparinus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heparin pentasaccharide	oligosaccharide products give bands between those for the heparin disaccharide and tetrasaccharide standards	Pedobacter heparinus	heparin oligosaccharides	-	?
additional information	a synthetic pentasaccharide containing an antithrombin III binding site serves as substrate	Pedobacter heparinus	additional information	a trisaccharide and a disaccharide with no antithrombin III binding activity	?

Synonyms

Synonyms	Comment	Organism
heparinase I	-	Pedobacter heparinus

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Release 2023.1 (January 2023)