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Literature summary for 4.2.2.5 extracted from
- Inhibition of hyaluronidases and chondroitinases by fatty acids (2002), J. Enzyme Inhib. Med. Chem., 17, 183-186.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (13Z)-docos-13-enoic acid | - |
Paenarthrobacter aurescens |  |
| (13Z)-docos-13-enoic acid | - |
Pedobacter heparinus | |
| arachidic acid | - |
Paenarthrobacter aurescens | |
| arachidic acid | weak inhibition | Pedobacter heparinus | |
| behenic acid | - |
Paenarthrobacter aurescens | |
| behenic acid | weak inhibition | Pedobacter heparinus | |
| capric acid | weak inhibition | Paenarthrobacter aurescens | |
| capric acid | weak inhibition | Pedobacter heparinus | |
| eicosadienoic acid | - |
Paenarthrobacter aurescens | |
| eicosadienoic acid | - |
Pedobacter heparinus | |
| eicosanoic acid | - |
Paenarthrobacter aurescens | |
| eicosanoic acid | - |
Pedobacter heparinus | |
| eicosapentaenoic acid | - |
Paenarthrobacter aurescens | |
| eicosapentaenoic acid | - |
Pedobacter heparinus | |
| eicosatetraenoic acid | - |
Paenarthrobacter aurescens | |
| eicosatetraenoic acid | - |
Pedobacter heparinus | |
| eicosatrienoic acid | - |
Paenarthrobacter aurescens | |
| eicosatrienoic acid | - |
Pedobacter heparinus | |
| elaidic acid | - |
Paenarthrobacter aurescens | |
| elaidic acid | - |
Pedobacter heparinus | |
| lauric acid | weak inhibition | Paenarthrobacter aurescens | |
| lauric acid | weak inhibition | Pedobacter heparinus | |
| linoleic acid | - |
Paenarthrobacter aurescens | |
| linoleic acid | - |
Pedobacter heparinus | |
| linolenic acid | - |
Paenarthrobacter aurescens | |
| linolenic acid | - |
Pedobacter heparinus | |
| methyl (9Z)-octadecenoate | weak inhibition | Paenarthrobacter aurescens | |
| methyl (9Z)-octadecenoate | weak inhibition | Pedobacter heparinus | |
| additional information | degree of inhibition by fatty acids depends on the chain length and the number of unsaturated bonds as well as the stereochemistry, overview | Paenarthrobacter aurescens | |
| additional information | degree of inhibition by fatty acids depends on the chain length and the number of unsaturated bonds as well as the stereochemistry, overview | Pedobacter heparinus | |
| myristic acid | - |
Paenarthrobacter aurescens | |
| myristic acid | weak inhibition | Pedobacter heparinus | |
| myristoleic acid | - |
Paenarthrobacter aurescens | |
| myristoleic acid | weak inhibition | Pedobacter heparinus | |
| nervonic acid | - |
Paenarthrobacter aurescens | |
| nervonic acid | - |
Pedobacter heparinus | |
| oleic acid | - |
Paenarthrobacter aurescens | |
| oleic acid | - |
Pedobacter heparinus | |
| palmitic acid | - |
Paenarthrobacter aurescens | |
| palmitic acid | weak inhibition | Pedobacter heparinus | |
| palmitoleic acid | - |
Paenarthrobacter aurescens | |
| palmitoleic acid | - |
Pedobacter heparinus | |
| petroselinic acid | - |
Paenarthrobacter aurescens | |
| petroselinic acid | - |
Pedobacter heparinus | |
| ricinoleic acid | - |
Paenarthrobacter aurescens | |
| ricinoleic acid | weak inhibition | Pedobacter heparinus | |
| stearic acid | - |
Paenarthrobacter aurescens | |
| stearic acid | weak inhibition | Pedobacter heparinus | |
| vaccenic acid | - |
Paenarthrobacter aurescens | |
| vaccenic acid | - |
Pedobacter heparinus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
chondroitin sulfate C | pH 6.0, 37°C | Pedobacter heparinus | |
| 0.0104 | - |
chondroitin sulfate C | pH 6.0, 37°C | Paenarthrobacter aurescens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paenarthrobacter aurescens | - |
- |
- |
| Pedobacter heparinus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine]n = n-1 4-deoxy-beta-D-gluc-4-enuronosyl-1,4-beta-D-hexosylamine + [1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine] | acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate | Pedobacter heparinus | |
| [1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine]n = n-1 4-deoxy-beta-D-gluc-4-enuronosyl-1,4-beta-D-hexosylamine + [1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine] | acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate | Paenarthrobacter aurescens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chondroitin sulfate C | i.e. chondroitin 6-sulfate | Pedobacter heparinus | ? | - |
? | |
| chondroitin sulfate C | i.e. chondroitin 6-sulfate | Paenarthrobacter aurescens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| c-ACI | - |
Pedobacter heparinus |
| c-ACII | - |
Paenarthrobacter aurescens |
| chondroitinase ACI | - |
Pedobacter heparinus |
| chondroitinase ACII | - |
Paenarthrobacter aurescens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Pedobacter heparinus |
| 37 | - |
assay at | Paenarthrobacter aurescens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
assay at | Paenarthrobacter aurescens |
| 7.3 | - |
assay at | Pedobacter heparinus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0047 | - |
nervonic acid | pH 6.0, 37°C | Paenarthrobacter aurescens | |
| 0.0211 | - |
eicosatrienoic acid | pH 6.0, 37°C | Pedobacter heparinus | |
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