Literature summary for 4.2.2.21 extracted from

Huang, Y.; Hsu, S.; Chen, M.; Hsieh, C.; Kuo, W.; Cheng, H.; Huang, Y.
Controlled release of chondroitinase ABC in chitosan-based scaffolds and PDLLA microspheres (2011), Carbohydr. Polym., 84, 788-793.

Search for more literature for 4.2.2.21

Application

Application	Comment	Organism
biotechnology	preservation of ChABC activity during release by immobilizing ChABC in chitosan nerve conduits and encapsulating ChABC in poly(DL-lactic acid) microspheres using an appropriate stabilizer. Immobilizing ChABC in nerve conduitss markedly improves its stability. The activity of ChABC that is immobilized in chitosan nerve conduits by ionic bonding is 0.07 U/mg. 48% of this activity is retained at 48 h after immobilization. Poly(DL-lactic acid) microspheres, fabricated by the double emulsion method, are applied as carriers in the controlled release of ChABC. Stabilizers, including nanogold of 10 nm, polylysine of Mw 500-2000 and polylysine of Mw 20000-30000, are added to microspheres to maintain the activity of ChABC. Polylysine stabilizes ChABC most effectively. The ChABC activity is 0.0162 U/ml after seven days of release	Proteus vulgaris
medicine	preservation of ChABC activity during release by immobilizing ChABC in chitosan nerve conduits and encapsulating ChABC in poly(DL-lactic acid) microspheres using an appropriate stabilizer. Immobilizing ChABC in nerve conduitss markedly improves its stability. The activity of ChABC that is immobilized in chitosan nerve conduits by ionic bonding is 0.07 U/mg. 48% of this activity is retained at 48 h after immobilization. Poly(DL-lactic acid) microspheres, fabricated by the double emulsion method, are applied as carriers in the controlled release of ChABC. Stabilizers, including nanogold of 10 nm, polylysine of Mw 500-2000 and polylysine of Mw 20000-30000, are added to microspheres to maintain the activity of ChABC. Polylysine stabilizes ChABC most effectively. The ChABC activity is 0.0162 U/ml after seven days of release	Proteus vulgaris

Organism

Organism	UniProt	Comment	Textmining
Proteus vulgaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Proteus vulgaris	-

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Release 2023.1 (January 2023)