Literature summary for 4.2.2.20 extracted from

Graham, J.B.; Neubauer, D.; Xue, Q.; Muir, D.
Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration (2007), Exp. Neurol., 203, 185-195.

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Application

Application	Comment	Organism
medicine	sciatic nerve transsection and end-to-end repair, with one nerve injected with chondroitinase ABC and the contralateral nerve treated with vehicle alone. Intrafascial retrograde axonal growth is equivalent in both control and chondroitinase treated conditions. Chondroitinase treatment causes a pronounced reduction in extrofacial retrograde axional growth. The decrease in axon egress from the nerve is coincident with an increase in antegrade regeneration and improved recovery of motor function	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sciatic nerve	sciatic nerve transsection and end-to-end repair, with one nerve injected with chondroitinase ABC and the contralateral nerve treated with vehicle alone	Rattus norvegicus	-

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Release 2023.1 (January 2023)