Literature summary for 4.2.2.2 extracted from

Ali, S.; Sondergaard, C.R.; Teixeira, S.; Pickersgill, R.W.
Structural insights into the loss of catalytic competence in pectate lyase activity at low pH (2015), FEBS Lett., 589, 3242-3246 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals grown at pH 4.0, to 1.57 A resolution	Bacillus subtilis

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	activity is lost at low pH because protonation of aspartates results in the loss of the two catalytic calcium-ions causing a profound failure to correctly organise the Michaelis complex	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	P39116	-	-
Bacillus subtilis 168	P39116	-	-

General Information

General Information	Comment	Organism
physiological function	activity is lost at low pH because protonation of aspartates results in the loss of the two catalytic calcium-ions causing a profound failure to correctly organise the Michaelis complex	Bacillus subtilis

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Release 2023.1 (January 2023)