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Literature summary for 4.2.2.1 extracted from
- Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan (2003), J. Enzyme Inhib. Med. Chem., 18, 377-382.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-isoascorbic acid | strong inhibition | Streptomyces hyalurolyticus |  |
| D-saccharic-1,4-lactone | strong inhibition | Streptomyces hyalurolyticus | |
| dehydroascorbic acid | - |
Streptomyces hyalurolyticus | |
| L-ascorbic acid | strong inhibition | Streptomyces hyalurolyticus | |
| additional information | poor inhibitors are alpha-D-glucoheptonic-gamma-lactone, L-gulonic-gamma-lactone, D-ribonic-gamma-lactone, and D-gluconic-gamma-lactone | Streptomyces hyalurolyticus | |
| saccharic acid | - |
Streptomyces hyalurolyticus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | - |
Streptomyces hyalurolyticus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces hyalurolyticus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate | lyase mechanism, elimination process | Streptomyces hyalurolyticus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Streptomyces hyalurolyticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronan + 2 H2O | from Streptococcus zooepidemicus, degradation | Streptomyces hyalurolyticus | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? | |
| additional information | hyaluronan is degraded by L-ascorbic acid, D-isoascorbic acid, and dehydroascorbic acid themselves, only slightly by L-gulonic-gamma-lactone, D-saccharic-1,4-lactone, and alpha-D-glucoheptonic-gamma-lactone | Streptomyces hyalurolyticus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bacterial HAse | - |
Streptomyces hyalurolyticus |
| bacterial hyaluronidase | - |
Streptomyces hyalurolyticus |
| hyaluronan lyase | - |
Streptomyces hyalurolyticus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Streptomyces hyalurolyticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Streptomyces hyalurolyticus |
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