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Literature summary for 4.2.1.96 extracted from

  • Li, W.; Gong, M.; Shu, R.; Li, X.; Gao, J.; Meng, Y.
    Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori (2015), Comp. Biochem. Physiol. B, 186, 20-27 .
    View publication on PubMed
Search for more literature for 4.2.1.96

Cloned(Commentary)

Cloned (Comment) Organism
PCD sequence comparisons and phylogenetic tree, enzyme expression analysis Bombyx mori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin Bombyx mori
-
 (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bombyx mori
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bombyx mori
-
imago
-
 Bombyx mori
-
larva third, forth, and fifth instar Bombyx mori
-
additional information PCD enzyme transcription profiles in different strains, expression analysis, overview. BmPcd is expressed almost throughout the whole life cycle Bombyx mori
-
ovariotestis
-
 Bombyx mori
-
pupa high expression level Bombyx mori
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin
-
 Bombyx mori (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O
-
 ?

Synonyms

Synonyms Comment Organism
PCD
-
 Bombyx mori
Pterin-4a-carbinolamine dehydratase
-
 Bombyx mori

General Information

General Information Comment Organism
malfunction in mutant phenotype lemon, the expression of BmDhpr is activated in the brain and sexual glands while BmPcd is expressed in a wider special pattern when the de novo pathway of BH4 is missing Bombyx mori
metabolism pterin-4a-carbinolamine dehydratase (PCD, BmPcd) and dihydropteridine reductase (DHPR, BmDhpr) might normally act in the regeneration pathway of Bombyx mori Bombyx mori
physiological function the regeneration pathway (RPB) of tetrahydrobiopterin (BH4), an essential cofactor of aromatic amino acid hydroxylases and nitric oxide synthase playing a key role in many biological processes, in Bombyx mori. The enzyme is involved in the insect BH4 biosynthetic networks, overview Bombyx mori