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Literature summary for 4.2.1.96 extracted from
- Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat (2003), Biochem. J., 373, 993-997.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glycerol | leads to a slight increase in enzyme activity only in the kidney, not in liver, when feeded as a 40% glycerol diet | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol | dietary glycerol leads to a small reduction in the mRNA level of the enzyme PCD/DCoH only in the liver, not in kidney, 40% glycerol diet lead to 2.5fold reduced activity in liver cytosol | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | enzyme plays a role in the regulation of expression of phenylalanine hydroxylase via transcription factor HNF1alpha | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0044 | - |
renal cytosol | Rattus norvegicus |
| 0.0134 | - |
hepatic cytosol | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin | - |
Rattus norvegicus | (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O | - |
? | |
| additional information | enzyme plays a role in the regulation of expression of phenylalanine hydroxylase via transcription factor HNF1alpha | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| additional information | the enzyme is identical with the dimerization cofactor DCoH, a cofactor for the hepatocyte nuclear factor 1alpha, HNF1alpha, which is essential for expression of phenylalanine hydroxylase PAH EC 1.14.16.1 | Rattus norvegicus |
| PCD | - |
Rattus norvegicus |
| PCD/DCoH | - |
Rattus norvegicus |
| Pterin-4a-carbinolamine dehydratase | - |
Rattus norvegicus |
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