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Literature summary for 4.2.1.96 extracted from

  • Rebrin, I.; Bailey, S.W.; Boerth, S.R.; Ardell, M.D.; Ayling, J.E.
    Catalytic characterization of 4alpha-hydroxytetrahydropterin dehydratase (1995), Biochemistry, 34, 5801-5810.
    View publication on PubMed
Search for more literature for 4.2.1.96

Inhibitors

Inhibitors Comment Organism Structure
Quinoid 6(S)-methyldihydropterin
-
 Rattus norvegicus
Quinoid 6(S)-propyldihydropterin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
 4a(R)-hydroxy-6(S)-propyltetrahydropterin pH 8.4 or pH 7.4 Rattus norvegicus
0.0025
-
 4a-Hydroxy-6(S)-methyltetrahydropterin pH 8.4 or pH 7.4 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information contains no metals Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4a(R)-hydroxy-6(S)-propyltetrahydropterin
-
 Rattus norvegicus quinoid 6(S)-propyldihydropterin
-
 ?
4a-Hydroxy-6(R)-dihydroxypropyltetrahydropterin
-
 Rattus norvegicus ?
-
 ?
4a-Hydroxy-6(S)-methyltetrahydropterin
-
 Rattus norvegicus Quinoid 6(S)-methyldihydropterin
-
 ?
4a-Hydroxy-6(S)-propyltetrahydropterin
-
 Rattus norvegicus Quinoid 6(S)-propyldihydropterin
-
 ?
additional information the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
additional information the enzyme has identical amino acid sequence to DCoH, the dimerization cofactor of the transcription regulator, HNF-1alpha Rattus norvegicus