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Literature summary for 4.2.1.96 extracted from

  • Koester, S.; Thoeny, B.; Macheroux, P.; Curtius, H.C.; Heizmann, C.W.; Pfleiderer, W.; Ghisla, S.
    Human pterin-4alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1alpha (1995), Eur. J. Biochem., 231, 414-423.
    View publication on PubMed
Search for more literature for 4.2.1.96

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant enzymes Homo sapiens

Protein Variants

Protein Variants Comment Organism
C81R mutant enzyme Cys81Arg has significantly lower activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12675
-
 4 * 12675, mutant enzyme C81S, electrospray-ionisation mass spectrometry Homo sapiens
12690
-
 4 * 12690, wild type enzyme, electrospray-ionisation mass spectrometry Homo sapiens
12744
-
 4 * 12744, mutant C81R, electrospray-ionisation mass spectrometry Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 wild type and mutant enzymes Cys81Ser and Cys81Arg
-

Purification (Commentary)

Purification (Comment) Organism
wild type and mutant enzymes Cys81Ser and Cys81Arg Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,6-dimethyl-4a-hydroxy-tetrahydropterin
-
 Homo sapiens 6,6-dimethyl-7,8-dihydropterin + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 12675, mutant enzyme C81S, electrospray-ionisation mass spectrometry Homo sapiens
tetramer 4 * 12690, wild type enzyme, electrospray-ionisation mass spectrometry Homo sapiens
tetramer 4 * 12744, mutant C81R, electrospray-ionisation mass spectrometry Homo sapiens