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Literature summary for 4.2.1.91 extracted from

  • Bross, C.D.; Corea, O.R.; Kaldis, A.; Menassa, R.; Bernards, M.A.; Kohalmi, S.E.
    Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana (2011), Plant Physiol. Biochem., 49, 882-890.
    View publication on PubMed
Search for more literature for 4.2.1.91

Cloned(Commentary)

Cloned (Comment) Organism
AtADT1, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana
AtADT2, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana
AtADT3, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana
AtADT4, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana
AtADT5, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana
AtADT6, DNA and amino acid sequence determination and analysis, sequence comparison, complementation of the Saccharomyces cerevisiae pha2 mutant strain YNL316c, which lacks PDT activity and cannot grow in the absence of exogenous Phe by the six ADTs from Arabidopsis thaliana: AtADT2 readily recovers the pha2 phenotype after about 6 days growth at 30°C, while AtADT1 requires about 13 days to show visible growth. By contrast, AtADT6, with lowest PDT activity, and AtADT3-5, with no PDT activity, are unable to recover the phenotype, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arogenate Arabidopsis thaliana
-
 L-phenylalanine + H2O + CO2
-
 ?
additional information Arabidopsis thaliana only AtADT1 and AtADT2, but not the other four ADTs from Arabidopsis thaliana, have functional PDT prephenate dehydratase, EC 4.2.1.51, activity in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O22241 isozyme AtADT4; isozymes AtADT1-AtADT6
-
Arabidopsis thaliana Q9FNJ8 isozyme AtADT5; isozymes AtADT1-AtADT6
-
Arabidopsis thaliana Q9SA96 isozyme AtADT1; isozymes AtADT1-AtADT6
-
Arabidopsis thaliana Q9SGD6 isozyme AtADT6; isozymes AtADT1-AtADT6
-
Arabidopsis thaliana Q9SSE7 isozyme AtADT2; isozymes AtADT1-AtADT6
-
Arabidopsis thaliana Q9ZUY3 isozyme AtADT3; isozymes AtADT1-AtADT6
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate
-
 Arabidopsis thaliana L-phenylalanine + H2O + CO2
-
 ?
additional information only AtADT1 and AtADT2, but not the other four ADTs from Arabidopsis thaliana, have functional PDT prephenate dehydratase, EC 4.2.1.51, activity in vivo Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
AdT
-
 Arabidopsis thaliana
AtADT1
-
 Arabidopsis thaliana
AtADT2
-
 Arabidopsis thaliana
AtADT3
-
 Arabidopsis thaliana
AtADT4
-
 Arabidopsis thaliana
AtADT5
-
 Arabidopsis thaliana
AtADT6
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution plant ADTs and prephenate dehydratases, EC 4.2.1.51, share many common features allowing them to act as dehydratase/decarboxylases, but group independently conferring distinct substrate specificities, sequence comparisons, overview Arabidopsis thaliana
metabolism The final steps of phenylalanine biosynthesis in bacteria, fungi and plants can occur via phenylpyruvate or arogenate intermediates. These routes are determined by the presence of prephenate dehydratase, EC 4.2.1.51, which forms phenylpyruvate from prephenate, or arogenate dehydratase, which forms phenylalanine directly from arogenate Arabidopsis thaliana