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Literature summary for 4.2.1.84 extracted from

  • Zheng, R.; Yin, X.; Zheng, Y.
    Highly regioselective and efficient production of 1-cyanocyclohexaneacetamide by Rhodococcus aetherivorans ZJB1208 nitrile hydratase (2016), J. Chem. Technol. Biotechnol., 91, 1314-1319 .
No PubMed abstract available
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Application

Application Comment Organism
synthesis the enzyme from Rhodococcus aetherivorans JB1208 shows high regioselectivity and strong substrate tolerance for alicyclic dinitrile and affords a potentially industrial route to gabapentin (a precursor of gamma-aminobutyric acid, which has been approved for treatment of a variety of central nervous system disorders, partial seizures, and restless legs syndrome) Rhodococcus aetherivorans

Organism

Organism UniProt Comment Textmining
Rhodococcus aetherivorans A0A2Z6FCE3 AND A0A2Z6FCD3 A0A2Z6FCE3: alpha-subunit, A0A2Z6FCD3: beta-subunit
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Rhodococcus aetherivorans JB1208 A0A2Z6FCE3 AND A0A2Z6FCD3 A0A2Z6FCE3: alpha-subunit, A0A2Z6FCD3: beta-subunit
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-cyanocyclohexaneacetonitrile + H2O
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 Rhodococcus aetherivorans 1-cyanocyclohexaneacetamide
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 ?
1-cyanocyclohexaneacetonitrile + H2O
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 Rhodococcus aetherivorans JB1208 1-cyanocyclohexaneacetamide
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 ?