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Literature summary for 4.2.1.84 extracted from

  • van Pelt, S.; Zhang, M.; Otten, L.G.; Holt, J.; Sorokin, D.Y.; van Rantwijk, F.; Black, G.W.; Perry, J.J.; Sheldon, R.A.
    Probing the enantioselectivity of a diverse group of purified cobalt-centred nitrile hydratases (2011), Org. Biomol. Chem., 9, 3011-3019.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ cobalt-dependent enzyme type Rhodopseudomonas palustris
Fe2+ iron-dependent enzyme type Rhodococcus erythropolis

Organism

Organism UniProt Comment Textmining
Rhodococcus erythropolis
-
-
-
Rhodococcus erythropolis AJ270
-
-
-
Rhodopseudomonas palustris
-
-
-
Rhodopseudomonas palustris CGA009
-
-
-
Rhodopseudomonas palustris HaA2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylpropionitrile + H2O the enzyme is highly enantioselective with the compound Rhodopseudomonas palustris 2-phenylpropionamide
-
?
2-phenylpropionitrile + H2O the enzyme is not enantioselective with the compound Rhodococcus erythropolis 2-phenylpropionamide
-
?
2-phenylpropionitrile + H2O the enzyme is highly enantioselective with the compound Rhodopseudomonas palustris HaA2 2-phenylpropionamide
-
?
2-phenylpropionitrile + H2O the enzyme is highly enantioselective with the compound Rhodopseudomonas palustris CGA009 2-phenylpropionamide
-
?
2-phenylpropionitrile + H2O the enzyme is not enantioselective with the compound Rhodococcus erythropolis AJ270 2-phenylpropionamide
-
?
3-(1-cyanoethyl)benzoic acid + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris ?
-
?
3-(1-cyanoethyl)benzoic acid + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris HaA2 ?
-
?
3-(1-cyanoethyl)benzoic acid + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris CGA009 ?
-
?
additional information analysis of enzyme enantioselectivity against a broad range of nitrile substrates, overview. At least one bulky group in close proximity to the alpha-position of the chiral nitriles seems to be necessary for enantioselectivity of NHases. Nitrile groups attached to a quaternary carbon atom are only reluctantly accepted and show no selectivity Rhodopseudomonas palustris ?
-
?
additional information analysis of enzyme enantioselectivity against a broad range of nitrile substrates, overview. The enzyme is aselective with a range of different 2-phenylacetonitriles. At least one bulky group in close proximity to the alpha-position of the chiral nitriles seems to be necessary for enantioselectivity of NHases. Nitrile groups attached to a quaternary carbon atom are only reluctantly accepted and show no selectivity Rhodococcus erythropolis ?
-
?
additional information analysis of enzyme enantioselectivity against a broad range of nitrile substrates, overview. At least one bulky group in close proximity to the alpha-position of the chiral nitriles seems to be necessary for enantioselectivity of NHases. Nitrile groups attached to a quaternary carbon atom are only reluctantly accepted and show no selectivity Rhodopseudomonas palustris HaA2 ?
-
?
additional information analysis of enzyme enantioselectivity against a broad range of nitrile substrates, overview. At least one bulky group in close proximity to the alpha-position of the chiral nitriles seems to be necessary for enantioselectivity of NHases. Nitrile groups attached to a quaternary carbon atom are only reluctantly accepted and show no selectivity Rhodopseudomonas palustris CGA009 ?
-
?
additional information analysis of enzyme enantioselectivity against a broad range of nitrile substrates, overview. The enzyme is aselective with a range of different 2-phenylacetonitriles. At least one bulky group in close proximity to the alpha-position of the chiral nitriles seems to be necessary for enantioselectivity of NHases. Nitrile groups attached to a quaternary carbon atom are only reluctantly accepted and show no selectivity Rhodococcus erythropolis AJ270 ?
-
?
naproxennitrile + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris ?
-
?
naproxennitrile + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris HaA2 ?
-
?
naproxennitrile + H2O the enzyme is enantioselective with the compound Rhodopseudomonas palustris CGA009 ?
-
?

Synonyms

Synonyms Comment Organism
NHase
-
Rhodopseudomonas palustris
NHase
-
Rhodococcus erythropolis