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Literature summary for 4.2.1.84 extracted from

  • Vesela, A.B.; Pelantova, H.; Sulc, M.; Mackova, M.; Lovecka, P.; Thimova, M.; Pasquarelli, F.; Picmanova, M.; Patek, M.; Bhalla, T.C.; Martinkova, L.
    Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in Rhodococci (2012), J. Ind. Microbiol. Biotechnol., 39, 1811-1819.
    View publication on PubMed

Application

Application Comment Organism
additional information Rhodococcus erythropolis A4 converts benzonitrile herbicides into amides, the strain is able to hydrolyze 2,6-dichlorobenzamide into 2,6-dichlorobenzoic acid, and produces also the carboxylic acids from the other herbicides. Transformation of nitriles into amides decreases acute toxicities for chloroxynil and dichlobenil, but increases them for bromoxynil and ioxynil. The amides inhibit root growth in Lactuca sativa less than the nitriles but more than the acids. The conversion of the nitrile group may be the first step in the mineralization of benzonitrile herbicides but cannot be itself considered to be a detoxification Rhodococcus erythropolis
additional information Rhodococcus rhodochrous PA-34 converts benzonitrile herbicides into amides, but the strain does not hydrolyze 2,6-dichlorobenzamide into 2,6-dichlorobenzoic acid. Transformation of nitriles into amides decreases acute toxicities for chloroxynil and dichlobenil, but increases them for bromoxynil and ioxynil. The amides inhibit root growth in Lactuca sativa less than the nitriles but more than the acids. The conversion of the nitrile group may be the first step in the mineralization of benzonitrile herbicides but cannot be itself considered to be a detoxification Rhodococcus rhodochrous

Organism

Organism UniProt Comment Textmining
Rhodococcus erythropolis
-
a soil isolate
-
Rhodococcus erythropolis A4
-
a soil isolate
-
Rhodococcus rhodochrous
-
a soil isolate
-
Rhodococcus rhodochrous PA-34
-
a soil isolate
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-dichlorobenzamide + H2O
-
Rhodococcus erythropolis 2,6-dichlorobenzoic acid
-
?
2,6-dichlorobenzamide + H2O
-
Rhodococcus erythropolis A4 2,6-dichlorobenzoic acid
-
?
benzonitrile + H2O
-
Rhodococcus rhodochrous benzamide
-
?
benzonitrile + H2O
-
Rhodococcus erythropolis benzamide
-
?
benzonitrile + H2O
-
Rhodococcus erythropolis A4 benzamide
-
?
benzonitrile + H2O
-
Rhodococcus rhodochrous PA-34 benzamide
-
?
bromoxynil + H2O
-
Rhodococcus rhodochrous ?
-
?
bromoxynil + H2O
-
Rhodococcus erythropolis ?
-
?
bromoxynil + H2O
-
Rhodococcus erythropolis A4 ?
-
?
bromoxynil + H2O
-
Rhodococcus rhodochrous PA-34 ?
-
?
chloroxynil acid + H2O
-
Rhodococcus rhodochrous ?
-
?
chloroxynil acid + H2O
-
Rhodococcus erythropolis ?
-
?
chloroxynil acid + H2O
-
Rhodococcus erythropolis A4 ?
-
?
chloroxynil acid + H2O
-
Rhodococcus rhodochrous PA-34 ?
-
?
chloroxynil amide + H2O
-
Rhodococcus rhodochrous ?
-
?
chloroxynil amide + H2O
-
Rhodococcus rhodochrous PA-34 ?
-
?
dichlobenil acid + H2O
-
Rhodococcus erythropolis ?
-
?
dichlobenil amide + H2O
-
Rhodococcus rhodochrous ?
-
?
dichlobenil amide + H2O
-
Rhodococcus erythropolis ?
-
?
ioxynil acid + H2O
-
Rhodococcus rhodochrous ?
-
?
ioxynil acid + H2O
-
Rhodococcus erythropolis ?
-
?
additional information no activity with 2,6-dichlorobenzamide and dichlobenil acid Rhodococcus rhodochrous ?
-
?
additional information no activity with chloroxynil amide Rhodococcus erythropolis ?
-
?
additional information no activity with chloroxynil amide Rhodococcus erythropolis A4 ?
-
?
additional information no activity with 2,6-dichlorobenzamide and dichlobenil acid Rhodococcus rhodochrous PA-34 ?
-
?