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Literature summary for 4.2.1.84 extracted from

  • Nagasawa, T.; Yamada, H.
    Nitrile hydratase is a quinoprotein. A possible new function of pyrroloquinoline: Activation of H2O in an enzymatic hydratation reaction (1987), Biochem. Biophys. Res. Commun., 147, 701-709.
    View publication on PubMed
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Application

Application Comment Organism
synthesis
-
 Brevibacterium sp.

Inhibitors

Inhibitors Comment Organism Structure
cysteamine 1 mM, 20 min at 15ºC Brevibacterium sp.
hydroxylamine 1 mM, 20 min at 15ºC Brevibacterium sp.
Penicillamine 1 mM, 20 min at 15ºC; L- and D-isomer Brevibacterium sp.
phenylhydrazine 1 mM, 20 min at 15ºC, irreversible Brevibacterium sp.
Semicarbazide 1 mM, 20 min at 15ºC Brevibacterium sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ direct binding of the substrate to the Fe(III)-active site of the enzyme Brevibacterium sp.
Fe2+ non-heme iron enzyme with a typical low-spin Fe(III)-active center Brevibacterium sp.

Organism

Organism UniProt Comment Textmining
Brevibacterium sp.
-
-
-
Brevibacterium sp. R312
-
-
-

Cofactor

Cofactor Comment Organism Structure
pyrroloquinoline quinone prosthetic group, covalently bound pyrroloquinoline quinone, PQQ or a compound which closely resembles PQQ Brevibacterium sp.