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Literature summary for 4.2.1.75 extracted from

  • Hart, G.J.; Battersby, A.R.
    Purification and properties of uroporphyrinogen III synthase (co-synthase) from Euglena gracilis (1985), Biochem. J., 232, 151-160.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information no bound cofactor Euglena gracilis

Inhibitors

Inhibitors Comment Organism Structure
Butane-2,3-dione 20% residual activity after 45 min at 40 mM Euglena gracilis
diethyl dicarbonate 10% residual activity after 5 min at 0.41 mM Euglena gracilis
NaN3 25-30% residual activity with 1.0 mM Euglena gracilis
Phenylglyoxal 50% residual activity after 1 min at 0.3 mM Euglena gracilis
pyridoxal 5'-phosphate
-
Euglena gracilis
uroporphyrinogen III product inhibition Euglena gracilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012 0.04 Hydroxymethylbilane
-
Euglena gracilis

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no metal ions present in enzyme Euglena gracilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
SDS-PAGE Euglena gracilis
38500
-
SDS-PAGE, gel filtration Euglena gracilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hydroxymethylbilane Euglena gracilis synthesis of uroporphyrinogen III, key intermediate for biosynthesis of tetrapyrrolic compounds like chlorophylls, hemes, cytochromes and vitamin B12 ?
-
?

Organism

Organism UniProt Comment Textmining
Euglena gracilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Euglena gracilis

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Euglena gracilis

Storage Stability

Storage Stability Organism
-70¦C, several weeks Euglena gracilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hydroxymethylbilane
-
Euglena gracilis Uroporphyrinogen III
-
?
Hydroxymethylbilane synthesis of uroporphyrinogen III, key intermediate for biosynthesis of tetrapyrrolic compounds like chlorophylls, hemes, cytochromes and vitamin B12 Euglena gracilis ?
-
?

Subunits

Subunits Comment Organism
monomer SDS-PAGE, gel filtration Euglena gracilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
enzyme assay at Euglena gracilis