Literature summary for 4.2.1.6 extracted from

Babbitt, P.C.; Hasson, M.S.; Wedekind, J.E.; Palmer, D.R.J.; Barrett, W.C.; Reed, G.H.; Rayment, I.; Ringe, D.; Kenyon, G.L.; Gerlt, J.A.
The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids (1996), Biochemistry, 35, 16489-16501.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O	it is proposed that the mechanism of the enzyme-catalyzed reaction is initiated by abstraction of the alpha-proton to form a stabilized enolic ion. If the substrate binds at the active site in the extended conformation the stereochemical course of the beta-elimination reaction is expected to be anti	Escherichia coli	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-galactonate	-	Escherichia coli	2-dehydro-3-deoxy-D-galactonate + H2O	-	?

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Release 2023.1 (January 2023)