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Literature summary for 4.2.1.54 extracted from

  • Baldwin, R.L.; Wood, W.A.; Emery, R.S.
    Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme A dehydrase (1965), Biochim. Biophys. Acta, 97, 202-213.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Megasphaera elsdenii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
enzyme consists of two proteins, EI and EII, neither of the two can catalyze the reaction alone, EI: 27000, EII: x * 41000 + x * 48000, SDS-PAGE Megasphaera elsdenii
48000
-
enzyme consists of two proteins, EI and EII, neither of the two can catalyze the reaction alone, EI: 27000, EII: x * 41000 + x * 48000, SDS-PAGE Megasphaera elsdenii
1000000
-
enzyme consists of two proteins, EI and EII, neither of the two can catalyze the reaction alone, EI: 27000 Da, EII: 10000000 Da, gel filtration Megasphaera elsdenii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lactoyl-CoA + H2O Megasphaera elsdenii enzyme in the pathway of propionate formation ?
-
?

Organism

Organism UniProt Comment Textmining
Megasphaera elsdenii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Megasphaera elsdenii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acrylyl-CoA + H2O
-
Megasphaera elsdenii lactoyl-CoA
-
?
lactoyl-CoA + H2O enzyme in the pathway of propionate formation Megasphaera elsdenii ?
-
?

Subunits

Subunits Comment Organism
polymer enzyme consists of two proteins, EI and EII, neither of the two can catalyze the reaction alone, EI: 27000, EII: x * 41000 + x * 48000, SDS-PAGE Megasphaera elsdenii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Megasphaera elsdenii

Cofactor

Cofactor Comment Organism Structure
ATP required, no stoichiometric hydrolysis of ATP Megasphaera elsdenii