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Literature summary for 4.2.1.49 extracted from
- Proposal for the mechanism of action of urocanase. Interference from the inhibition by 2-methylurocanate (1987), Z. Naturforsch. C, 42, 349-352.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Methylimidazolone propionate | - |
Pseudomonas putida |  |
| 2-Methylurocanate | - |
Pseudomonas putida | |
| hydroxylamine | - |
Pseudomonas putida | |
| Imidazolepropionate | competitive | Pseudomonas putida | |
| NaBH4 | - |
Pseudomonas putida | |
| O-Methylhydroxylamine | - |
Pseudomonas putida | |
| Sodium dithionite | - |
Pseudomonas putida | |
| sulfite | - |
Pseudomonas putida | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Urocanate + H2O | Pseudomonas putida | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas putida | - |
ATCC 11299 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O | reaction mechanism | Pseudomonas putida |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-Methylurocanate + H2O | - |
Pseudomonas putida | 2-Methylimidazolone propionate | - |
? | |
| Urocanate + H2O | - |
Pseudomonas putida | 4,5-Dihydro-4-oxo-5-imidazolepropanoate | - |
? | |
| Urocanate + H2O | - |
Pseudomonas putida | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Pseudomonas putida | |
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