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Literature summary for 4.2.1.47 extracted from

  • Sullivan, F.X.; Kumar, R.; Kriz, R.; Stahl, M.; Xu, G.Y.; Rouse, G.; Chang, X.J.; Boodhoo, A.; Potvin, B.; Cumming, D.A.
    Molecular cloning of human GDP-mannose 4,6-Dehydratase and reconstitution of GDP-fucose biosynthesis in vitro (1998), J. Biol. Chem., 273, 8193-8202.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NADPH activates Escherichia coli
NADPH activates Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GDP-L-fucose
-
Escherichia coli
GDP-L-fucose
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
GDPmannose
-
Homo sapiens
0.26
-
GDPmannose
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDPmannose Escherichia coli
-
?
-
?
GDPmannose Homo sapiens synthesis of various glycoconjugates ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
additional information including cultured cells Homo sapiens
-
pancreas
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
thymus
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.11
-
-
Homo sapiens
0.73
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-mannose
-
Escherichia coli GDP-4-dehydro-6-deoxy-D-mannose + H2O
-
?
GDP-mannose
-
Homo sapiens GDP-4-dehydro-6-deoxy-D-mannose + H2O
-
?
GDPmannose
-
Escherichia coli ?
-
?
GDPmannose synthesis of various glycoconjugates Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Escherichia coli
37
-
assay at Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+ strict requirement, cannot be substituted by NAD+ Escherichia coli
NADP+ strict requirement, cannot be substituted by NAD+ Homo sapiens