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Literature summary for 4.2.1.46 extracted from

  • Allard, S.T.; Giraud, M.F.; Whitfield, C.; Graninger, M.; Messner, P.; Naismith, J.H.
    The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar typhimurium, the second enzyme in the dTDP-l-rhamnose pathway (2001), J. Mol. Biol., 307, 283-295.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
structure determined to 2.47 A resolution with its cofactor NAD+ bound, sitting drop method Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-glucose Salmonella enterica
-
 dTDP-4-dehydro-6-deoxy-D-glucose + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 serovar typhimurium
-

Purification (Commentary)

Purification (Comment) Organism
-
 Salmonella enterica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-glucose
-
 Salmonella enterica dTDP-4-dehydro-6-deoxy-D-glucose + H2O
-
 ?
dTDP-glucose second enzyme in the dTDP-L-rhamnose pathway Salmonella enterica dTDP-4-dehydro-6-deoxy-D-glucose + H2O
-
 ?

Subunits

Subunits Comment Organism
More the enzyme functions as a homodimer with monomer association occuring principally through hydrophobic interactions via a four-helix bundle Salmonella enterica

Synonyms

Synonyms Comment Organism
RmlB
-
 Salmonella enterica

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Salmonella enterica