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Literature summary for 4.2.1.39 extracted from

  • Sutter, J.M.; Taestensen, J.B.; Johnsen, U.; Soppa, J.; Schoenheit, P.
    Key enzymes of the semiphosphorylative Entner-Doudoroff pathway in the haloarchaeon Haloferax volcanii characterization of glucose dehydrogenase, gluconate dehydratase, and 2-keto-3-deoxy-6-phosphogluconate aldolase (2016), J. Bacteriol., 198, 2251-2262 .
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3
-
 D-gluconate pH 7.5, 42°C Haloferax volcanii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
340000
-
 gel filtration Haloferax volcanii

Organism

Organism UniProt Comment Textmining
Haloferax volcanii D4GYD4
-
-
Haloferax volcanii DSM 3757 D4GYD4
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
30
-
 pH 7.5, 42°C Haloferax volcanii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-galactonate low activity Haloferax volcanii 2-dehydro-3-deoxy-D-galactonate + H2O
-
 ?
D-galactonate low activity Haloferax volcanii DSM 3757 2-dehydro-3-deoxy-D-galactonate + H2O
-
 ?
D-gluconate
-
 Haloferax volcanii 2-dehydro-3-deoxy-D-gluconate + H2O
-
 ?
D-gluconate
-
 Haloferax volcanii DSM 3757 2-dehydro-3-deoxy-D-gluconate + H2O
-
 ?
additional information the enzyme catalyzes the specific dehydration of gluconate and does not utilize galactonate at significant rates Haloferax volcanii ?
-
 ?
additional information the enzyme catalyzes the specific dehydration of gluconate and does not utilize galactonate at significant rates Haloferax volcanii DSM 3757 ?
-
 ?

Subunits

Subunits Comment Organism
octamer 8 * 45800, calculated from sequence Haloferax volcanii

Synonyms

Synonyms Comment Organism
GAD
-
 Haloferax volcanii
HVO_1488
-
 Haloferax volcanii

General Information

General Information Comment Organism
physiological function a knockout mutant of GAD loses the ability to grow on glucose. Following a prolonged incubation period, GAD is functionally replaced by xylonate dehydratase Haloferax volcanii