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Literature summary for 4.2.1.36 extracted from

  • Do, E.; Park, M.; Hu, G.; Caza, M.; Kronstad, J.W.; Jung, W.H.
    The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans (2016), Biochem. Biophys. Res. Commun., 477, 706-711 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans var. grubii
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Synonyms

Synonyms Comment Organism
LYS4
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 Cryptococcus neoformans var. grubii

Expression

Organism Comment Expression
Cryptococcus neoformans var. grubii transcription factors HAP3 or HAPX negatively regulate expression of the gene, but only in iron-depleted conditions. The transcription factors do not influence LYS4 transcript levels upon iron repletion down
Cryptococcus neoformans var. grubii no LYS4 transcripts are observed in cells grown in low-iron medium, whereas abundant transcripts are observed in the cells grown in the high-iron medium. These results confirm the regulation of LYS4 by iron availability and indicate that the LYS4 gene is mainly transcribed when sufficient iron is present in the environment. Iron availability influences both transcript and protein levels for Lys4 up

General Information

General Information Comment Organism
malfunction deletion of the LYS4 gene results in lysine auxotrophy. The mutant shows increased sensitivity to oxidative stress, agents that challenge cell wall/membrane integrity, and azole antifungal drugs Cryptococcus neoformans var. grubii
metabolism the enzyme is involved in the lysine biosynthetic pathway Cryptococcus neoformans var. grubii
physiological function Lys4 plays an important role in mitochondrial iron metabolism, and is required for proper mitochondrial function in Cryptococcus neoformans. LYS4 is required for full virulence in Cryptococcus neoformans Cryptococcus neoformans var. grubii